missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 30000014

Tocris Bioscience™ FHT 1015
GREENER_CHOICE

Product Code. 30000014
Click to view available options
Quantity:
2 mg
Unit Size:
2mg
This item is not returnable. View return policy

Product Code. 30000014

Brand: Tocris Bioscience™ 7644/2

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Potent and selective SMARCA4/2 inhibitor

FHT 1015 is a potent and selective allosteric inhibitor of SMARCA4/SMARCA2 ATPase (also known as BRG1/BRM respectively) of the BAF (BRG/Brahma-associated factors) complex, with IC50s of ≤ 10 nM. Exhibits selectivity for SMARCA4/SMARCA2 over related CHD4 (IC50 of > 400 μM). Mutations in I1143 on SMARCA4 and I1173 on SMARCA2 render these proteins resistant to inhibition by FHT 1015. The compound induces lineage-specific changes in chromatin accessibility in different cancer cell lines, preventing binding of cancer-associated transcription factors, SOX10 and MITF transcription factors.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (S)-1-(Methylsulfonyl)-N-[4-(methylthio)-1-oxo-1-[[4-[3-(pyridin-4-yl)phenyl]thiazol-2-yl]amino]butan-2-yl]-1H-pyrrole-3-carboxamide
CAS 2368903-18-6
Quantity 2 mg
Target Bromodomain Inhibitors
Molecular Formula C25H25N5O4S3
Purity 0.95
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.