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Invitrogen™ Filamin A alpha-2 Polyclonal Antibody

Description
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse kidney, PC-12, Rat2. Predicted reactivity: Mouse (98%), Rat (98%), Rabbit (98%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Specifications
Specifications
| Antigen | Filamin A alpha-2 |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.42 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 |
| Gene | FLNA |
| Gene Accession No. | P21333, Q8BTM8 |
| Gene Alias | ABP-280; ABPX; actin binding protein 280; actin-binding protein 280; alpha filamin; alpha-filamin; CSBS; CVD1; dilated pupils 2; Dilp2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); F730004A14Rik; filamin A; filamin A, alpha; filamin, alpha; filamin-1; Filamin-A; FLN; FLN1; FLNA; FLN-A; FMD; GENA 379; MNS; NHBP; Non-muscle filamin; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD |
| Gene Symbols | FLNA |
| Show More |
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