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SNAI2 Monoclonal Antibody (OTI2F3), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA800154
This item is not returnable.
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Description
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.Specifications
| SNAI2 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| O43623 | |
| SNAI2 | |
| Full length human recombit protein of human SNAI2 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Western Blot | |
| OTI2F3 | |
| Unconjugated | |
| SNAI2 | |
| SLUG, SLUGH, SLUGH1, SNAIL2, WS2D | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 6591 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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