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FM-381, MedChemExpress

Product Code. 16453698
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Product Code. 16453698

Brand: Medchem Express HY102046

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Description

MedChemExpress FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

Specifications

Chemical Name or Material FM-381
CAS 2226521-65-7
Color Yellow
Purity Grade Notes Research
Molecular Formula C24H24N6O2
Quantity 10 mg
Solubility Information DMSO : 8.33 mg/mL (19.44 mM; Need ultrasonic)
SMILES CN(C(/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)O1)=O)C
Molecular Weight (g/mol) 428.49
Formula Weight 428.49
Percent Purity 98.25%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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