Invitrogen™ FUT8 Polyclonal Antibody

Description

Immunogen sequence: MTDLYYLSQTD GAGDWREKEA KDLTELVQRR ITYLQNPKDC SKAKKLVCNI NKGCGYGCQL HHVVYCFMIA YGTQRTLILE SQNWRYATGG WETVFRP Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.

Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.