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Invitrogen™ G0S2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5100248
This item is not returnable.
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Description
Antibody detects endogenous levels of total G0S2.
The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.
Specifications
| G0S2 | |
| Polyclonal | |
| Unconjugated | |
| G0s2 | |
| AI255151; AV006465; G0/G1 switch 2; G0/G1 switch gene 2; G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; G0s2; G0S2-like protein; putative lymphocyte G0/G1 switch; Putative lymphocyte G0/G1 switch gene; putative lymphocyte G0/G1 switch protein 2; RP1-28O10.2 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 14373, 50486 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P27469, Q61585 | |
| G0s2 | |
| A synthesized peptide derived from human G0S2(Accession P27469), corresponding to amino acid residues R54-S103. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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