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Invitrogen™ GAD67 Recombinant Rabbit Monoclonal Antibody (HL1096)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA550303
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Description
GAD67 Recombinant Monoclonal Antibody for Western Blot, IHC, IHC (P)
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
Specifications
| GAD67 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative | |
| A0PA85, P14748, P18088, P48318, Q99259 | |
| GAD1 | |
| Recombinant protein encompassing a sequence within the center region of human GAD67. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat, Canine, Feline, Zebrafish | |
| Antibody | |
| IgG |
| Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| HL1096 | |
| Unconjugated | |
| GAD1 | |
| 67 kDa glutamic acid decarboxylase; 67kDa glutamate decarboxylase 1; CPSQ1; EGK_04525; EP10; FLJ45882; GAD; GAD 1; GAD 67; GAD1; Gad-1; GAD25; GAD44; Gad67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 isoform GAD67; glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase; glutamic acid decarboxylase 1; glutamic acid decarboxylase isoform 67; OTTHUMP00000041055; SCP | |
| Rabbit | |
| Protein A | |
| RUO | |
| 14415, 24379, 2571, 478794, 493699 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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