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Invitrogen™ GBL Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA520127
This item is not returnable.
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Description
A suggested positive control is human brain tissue lysate. PA5-20127 can be used with blocking peptide PEP-0245.
G-protein beta subunit like (GBL protein) is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin-receptor activation including insulin-stimulated glucose transport and glycogen synthesis. Northern Blot analysis detected a ubiquitous expression of LST8 with highest expression in brain and testis.
Specifications
| GBL | |
| Polyclonal | |
| Unconjugated | |
| MLST8 | |
| 0610033N12Rik; AA409454; AI505104; AI851821; G beta-like protein; G protein beta subunit-like; Gable; GbetaL; GBL; GBL protein; Lst8; Mammalian lethal with SEC13 protein 8; mLST8; mLST8 / mLST8; MTOR associated protein, LST8 homolog; MTOR associated protein, LST8 homolog (S. cerevisiae); POP3; protein GbetaL; Target of rapamycin complex subunit LST8; TORC subunit gable; TORC subunit LST8; TORC subunit WAT1; transducin (beta)-like 4; WAT1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 56716, 64223, 64226 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunohistochemistry, Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q9BVC4, Q9DCJ1, Q9Z2K5 | |
| MLST8 | |
| A 14 amino acid peptide from near the carboxy terminus of human GbL. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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