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GEMIN2 Monoclonal Antibody (OTI6G4), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA808823
This item is not returnable.
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Description
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.Specifications
| GEMIN2 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| O14893 | |
| GEMIN2 | |
| Full length human recombit protein of human SIP1 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI6G4 | |
| Unconjugated | |
| GEMIN2 | |
| SIP1, SIP1-delta | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 8487 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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