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Invitrogen™ GLRB Polyclonal Antibody

Product Code. 15564171
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
15564171 100 μL 100µL
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Product Code. 15564171 Supplier Invitrogen™ Supplier No. PA536958

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 58 kDa. Purity is >95% by SDS-PAGE.

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GLRB
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide; pH 7.2
Gene GLRB
Gene Accession No. P20781, P48167, P48168
Gene Alias AI853901; Glrb; glycine receptor; Glycine receptor 58 kDa subunit; glycine receptor beta; glycine receptor subunit beta; glycine receptor, beta; glycine receptor, beta subunit; GlyR beta; Glyrb; HKPX2; inhibitory glycine receptor; spa; spastic
Gene Symbols GLRB
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 252-297 of human GLRB.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14658, 25456, 2743
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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