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Invitrogen™ GNA13 Polyclonal Antibody
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Product Code. 15556962
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Quantity:
100 μL
Unit Size:
100µL
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15556962 100 μL 100µL
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Product Code. 15556962 Supplier Invitrogen™ Supplier No. PA545827

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Description

Rabbit Polyclonal Antibody

Peptide sequence: SREKTYVKRL VKILLLGAGE SGKSTFLKQM RIIHGQDFDQ RAREEFRPTI.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen GNA13
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene GNA13
Gene Accession No. Q14344
Gene Alias AU024132; AU043124; G alpha 13; G alpha-13; G protein subunit alpha 13; G13; Galpha 13; Galpha13; Gna13; Gna-13; G-protein subunit alpha-13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; guanine nucleotide-binding protein subunit alpha-13
Gene Symbols GNA13
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human GNA13 (aa 39-88).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10672
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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