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Tocris Bioscience™ Go 6976

Product Code. 18094722
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Quantity:
500 μg
Unit Size:
500µg
This item is not returnable. View return policy

Product Code. 18094722

Brand: Tocris Bioscience™ 2253/500U

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This item is not returnable. View return policy

Description

Potent protein kinase C inhibitor; selective for α and β isozymes

Go 6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
CAS 136194-77-9
Quantity 500 μg
Target Protein Kinase C Inhibitors
Molecular Formula C24H18N4O
Purity 95%
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