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Invitrogen™ GPRC6A Polyclonal Antibody
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Product Code. 15382361
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Quantity:
50 μg
Unit Size:
50µg
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15382361 50 μg 50µg
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Product Code. 15382361 Supplier Invitrogen™ Supplier No. PA533810

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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%) Dog, Hamster, Elephant (82%).

GPRC6A is an Orphan-U GPCR with an unknown ligand. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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Specifications

Antigen GPRC6A
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene GPRC6A
Gene Accession No. Q5T6X5
Gene Alias bA86F4.3; G protein-coupled receptor class C group 6 member A; G protein-coupled receptor, class C, group 6, member A; G protein-coupled receptor, family C, group 6, member A; GPCR; Gprc6a; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33; hGPCR33; hGPRC6A; predicted with SOSUI analysis; seven transmembrane helix receptor
Gene Symbols GPRC6A
Host Species Rabbit
Immunogen Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GPRC6A.
Purification Method Antigen Affinity Chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 222545
Target Species Human, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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