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  6. Epredia™ Lab Vision™ Granzyme B Ab-1, Mouse Monoclonal Antibody

Epredia™ Lab Vision™ Granzyme B Ab-1, Mouse Monoclonal Antibody

Product Code. 12649136 Shop All Epredia Products
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100 μL
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12 mL
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12649136 100 μL Concentrated 100µL
12659136 500 μL Concentrated 500µL
12639136 1 mL Concentrated 1mL
12629136 7 mL Prediluted 7mL
12619136 12 mL Ready-to-Use 12mL
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Product Code. 12649136 Supplier Epredia™ Supplier No. MS1157S0

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Description

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Granzyme B Ab-1, Mouse Monoclonal Antibody.

Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified. One of these, human granzyme B, is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. Exocytosis of granzyme-containing granules in the cytoplasm of the target cell leads to the induction of DNA fragmentation and apoptosis.

Host Species: Mouse

Clone: GZB01

Isotype: IgG2a

Species Reactivity: Human. Others not known.

Epitope: N-terminal

Immunogen: Recombinant protein encoding the N-terminus of the mature granzyme B

Molecular Weight: 32 kDa

Positive Control: Hodgkin's lymphoma, Tonsil

Cellular Localization: Granular cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin only)
TRUSTED_SUSTAINABILITY

Specifications

Antigen Granzyme B Ab-1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone GZB01
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant protein encoding the N-terminus of the mature granzyme B
Purification Method Hodgkin's lymphoma
Quantity 100 μL
Regulatory Status IVD
Research Discipline Apoptosis
Primary or Secondary Primary
Target Species Human
Form Concentrated
Isotype IgG2a
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