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Invitrogen™ Granzyme K Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5100743
This item is not returnable.
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Description
Antibody detects endogenous levels of total Granzyme K.
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
Specifications
| Granzyme K | |
| Polyclonal | |
| Unconjugated | |
| GZMK | |
| Fragmentin-3; granzyme 3; granzyme K; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); granzyme-3; GrK; GZMK; NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2; TRYP2; tryptase II | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 14945, 29165, 3003 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O35205, P49863, P49864 | |
| GZMK | |
| A synthesized peptide derived from human GZMK(Accession P49863), corresponding to amino acid residues A65-N115. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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