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Invitrogen™ GSDMD Recombinant Rabbit Monoclonal Antibody (HL1430)
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Product Code. 17879505
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
17879505 100 μL 100µL
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Product Code. 17879505 Supplier Invitrogen™ Supplier No. MA547041

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Description

Rabbit Recombinant Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GSDMD
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone HL1430
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene GSDMD
Gene Accession No. P57764
Gene Alias 1810036L03Rik; AW558049; DF5L; Dfna5l; FKSG10; gasdermin D; gasdermin domain containing 1; gasdermin domain-containing protein 1; Gasdermin-D; Gasdermin-D, C-terminal; Gasdermin-D, N-terminal; GSDMD; GSDMDC1; GSDMD-CT; GSDMD-NT; M2-4
Gene Symbols GSDMD
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of Human Gasdermin D. The exact sequence is proprietary.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79792
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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