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Tocris Bioscience™ GW 2580
Selective cFMS kinase inhibitor; orally bioavailable
Brand: Tocris Bioscience™ 5673/50
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Description
GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.Specifications
| 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine | |
| 870483-87-7 | |
| 50 mg |
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