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Description
The HM β 1-1 monoclonal antibody specifically binds to the 130-kDa integrin β 1 chain (CD29). CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin- α chains. With α 1 through α 6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with α v (CD51), it forms α α 8, and α 9 chains in non-lymphoid tissues. As a result, CD29 has a broad tissue distribution, including lymphocytes, endothelia, smooth muscle, epithelia, and oocytes. This hamster mAb to a mouse leukocyte antigen has been observed to crossreact with similar populations of rat leukocytes. Source of the immunogen was purified mouse VLA-4 ( α 4β 1, CD49d/CD29).
The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
Specifications
| CD29 | |
| Monoclonal | |
| 0.2mg/mL | |
| Itgb1; Integrin beta-1; Fnrb; gpIIa; VLA-4 subunit beta | |
| Hamster | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2 λ1 |
| Flow Cytometry | |
| HM β1-1 | |
| Brilliant Violet 711 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Purified mouse VLA-4 | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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