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Eurofins DiscoverX Hck Protein, Active

Product Code. 17320374
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250 μg
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250µg
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17320374 10 μg 10µg
17330374 250 μg 250µg
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Product Code. 17320374 Supplier Eurofins DiscoverX Supplier No. 14577

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Description

Active, N-terminal His6-tagged, recombinant, human Hck, amino acids 230-497, for use in Kinase Assays.

Hematopoietic cell kinase (HCK) is a member of Src protein-tyrosine kinase family and expressed primary in granulocytes, monocytes and macrophages. Active HCK phosphorylates STAT5B on Tyr699, which represents an essential step in Signal transducer and activator of transcription 5 (STAT5B) stimulation. The binding of SH3 ligands, such as the Nef protein of HIV-1, further augments Hck activity suggesting a new mechanism for regulating tyrosine kinase activity.

GenBank NM_002110

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 34.1 kDa
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal 6His
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Truncated
Purity or Quality Grade ≥59%
Protein Hck, active
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