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HDAC1 Polyclonal Antibody, Alexa Fluor™ 488, Invitrogen™

Product Code. 15957284
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50 μL
Unit Size:
50µL
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15957284 50 μL 50µL
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Product Code. 15957284 Supplier Invitrogen Supplier No. PA1860A488

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Description

Rabbit Polyclonal Antibody

PA1860A488 detects histone deacetylase 1 (HDAC1) from human, mouse, rat, hamster and canine tissues and cells. The PA1860A488 immunogen is a synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1. This immunizing peptide (Cat. No. PEP-069) is available for use in neutralization and control experiments.

Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p. HDAC1 is a class I histone deacetylase containing 482 amino acid residues. HDAC1 has been shown to interact directly with transcription factors and has been shown to deacetylate histone proteins H3 and H4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HDAC1
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene HDAC1
Gene Accession No. Q13547, O09106, Q4QQW4
Gene Alias HD1, RPD3L1, GON-10, RP4-811H24.2, RPD3, MommeD5, Hdac1-ps
Gene Symbols HDAC1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1
Purification Method Antigen affinity chromatography
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100752721, 297893, 3065, 433759, 487309
Target Species Canine, Hamster, Human, Mouse, Rat
Content And Storage 4° C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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