Heavy chain of IgG4 Mouse anti-Human, Clone: 1A1A2, Proteintech

Description

This antibody detects the heavy chain of human IgG4. The immunogen of this antibody is the specific domain NKGLPSSIEK of IGHG4.

The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Several studies have shown that a large population of patients with recurrent respiratory tract infection have low IgG4 concentrations.