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Invitrogen™ HES4 Polyclonal Antibody
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Product Code. 15528012
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Quantity:
100 μg
Unit Size:
100µg
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15528012 100 μg 100µg
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Product Code. 15528012 Supplier Invitrogen™ Supplier No. PA547518

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Description

Sheep Polyclonal Antibody

In direct ELISAs and Western blots, this antibody shows less than 1% cross-reactivity with recombinant human (rh) HES-1, rhHES-2, rhHES-5, and rhHES-7. Reconstitute at 0.2 mg/mL in sterile PBS.

HES4, or Hes Family BHLH Transcription Factor 4, is a gene located on chromosome 1p36.31, encoding a basic helix-loop-helix (bHLH) transcription factor that plays a role in the Notch signaling pathway. This pathway is integral to cell differentiation, proliferation, and apoptotic processes, especially during embryonic development and tissue homeostasis. HES4 acts as a transcriptional repressor, regulating the expression of genes responsible for maintaining stem cell populations and inhibiting premature differentiation. While its exact biological roles are still being elucidated, studies suggest HES4 influences neurogenesis and myogenesis by modulating the timing of differentiation events within progenitor cells. The dysregulation of HES4 can impact normal developmental processes, potentially contributing to pathologies such as cancer and developmental disorders due to its control over cellular growth and differentiation pathways. Research into HES4 continues to advance understanding of its functions within the context of Notch signaling and its implications for disease.
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Specifications

Antigen HES4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene HES4
Gene Accession No. Q9HCC6
Gene Alias bHLH factor Hes4; bHLHb42; Class B basic helix-loop-helix protein 42; hairy and enhancer of split 4; hes family bHLH transcription factor 4; HES4; hHES4; transcription factor HES-4
Gene Symbols HES4
Host Species Sheep
Immunogen E. coli-derived recombinant human HES-4 Val94-Arg221.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57801
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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