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Cytiva HiTrap™ MabSelect™ Prepacked Columns
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Quantity:
1 x 5 mL
5 x 1 mL
5 x 5 mL
Product Line:
MabSelect
MabSelect™ Xtra
Unit Size:
Each
Pack of 5
Description
Prepacked HiTrap columns for process development, screening of purification conditions, and small-scale purification of Mabs. MabSelect media are suited for the high flowrates and pressures required when scaling up.
- Oriented coupling of recombinant Protein A ligand to the agarose matrix via an engineered C-terminal cysteine increases IgG binding capacity over other protein A media
- High capacity, low ligand leakage, and high-flow base matrix allow purification of Mabs at process scale
- Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification
- Designed for use with a syringe, a peristaltic pump, or a chromatography system
MabSelect
- Allows at least five times higher flowrates than conventional cross-linked agarose of similar porosity
- Recombinant Protein A ligand promotes specificity of binding to Fc region of IgG; permits one-step purification
- Same recombinant protein A ligand as MabSelect, but with a smaller particle size and greater porosity, for increased dynamic binding capacity
- Allows binding from samples with high expression levels of the monoclonal antibody
- Lowers overall production cost due to the possibility of processing concentrated feedstocks in fewer batches
- Akali-tolerant protein A-derived ligand allows the use of up to 0.5M NaOH for cleaning-in-place (CIP)
- Permits significant cost savings and extension of cycles in regular production
Specifications
Specifications
| Product Type | Pre-packed Columns |
| Product Line | MabSelect |
| Binding Capacity | ∼30 mg/mL Human lgG at 2.4 min. residence time |
| Diameter (Metric) Inner Column | 1.6 cm |
| Diameter (English) Inner Column | 0.62 in. |
| Flow Rate | <20 mL/min. |
| Volume (Metric) Bed | 5 mL |
| For Use With (Application) | For fast purification of monoclonal antibodies from large sample volumes, Protein Purification |
| Description | HiTrap MabSelect columns are prepacked with MabSelect, a BioProcess resin for capturing of mAbs from large sample volumes. |
| Sample Volume | 5 mL |
| Show More |
Safety and Handling
Product Identifier
- HiTrap MabSelect, 5 ml, 5 x 5 ml
- Warning
- Flammable liquid Category 3
- H226-Flammable liquid and vapour.
- P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P241-Use explosion-proof electrical/ventilating/lighting/ equipment.
- P260-Do not breathe dust/fume/gas/mist/vapours/spray.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : ethanol
- UNKNOWN ACUTE-16.5 per cent of the mixture consists of component(s) of unknown acute toxicity.
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