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HLA-E Mouse anti-Human, CoraLite 488, Clone: 1A4G3, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech CL488-66530-100UL
This item is not returnable.
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Description
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I and class II. This class I molecules are membrane glycoproteins composed of a heavy (alpha) chain which is encoded by a HLA class I gene, and β2-microglobulin light (beta) chain. The most extensively characterized members of the HLA class I gene family are the genes encoding the major transplantation antigenes, HLA-A, B and C. HLA-E is a non-classical MHC class I molecule. HLA-E is frequently overexpressed in tumor diseases, transplants and virus-infected cells and represents an immunomodulatory molecule by binding to the receptors CD94/NKG2A, -B and -C on NK and T cells. Due to its immune suppressive features HLA-E expression might represent an important mechanism of tumors to escape immune surveillance.(PMID: 667938; 3375250; 2249951; 27589686)
Specifications
| HLA-E | |
| Monoclonal | |
| 1000 μg/mL | |
| Mouse | |
| Primary | |
| Human | |
| IgG2a |
| Western Blot | |
| 1A4G3 | |
| CoraLite 488 | |
| 100 μL | |
| 3133 | |
| Liquid |
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