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HLA-G Monoclonal Antibody (87G), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
€ 78.50 - € 129.00
Specifications
Antigen | HLA-G |
---|---|
Clone | 87G |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry, Immunohistochemistry (Frozen) |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15238277
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Affymetrix eBioscience
14-9957-82 |
100 μg |
€ 129.00
100µg |
In Stock Log in to see stock. |
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15228277
|
Affymetrix eBioscience
14-9957-80 |
25 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The monoclonal antibody 87G recognizes human HLA-G, a member of the Human Leukocyte Antigen family but as part of the nonclassical MHC type involved in inhibiting immune reponses. HLA-G has seven reported isoforms. The antibody 87G recognizes both HLA-G1 and the solube HLA-G5. Expression of HLA-G is found primarily in fetal trophoblast cells as they invade the maternal decidua thereby protecting the fetus from the maternal immune system. Like the highly mitotic trophoblast, abundant HLA-G protein expression has been identified in some tumors, including melanoma, breast carcinoma and renal carcinoma as well as CLL, AML and B-CLL. Some expression has also been found in pancreatic islets, erythroid and endothelial progenitors and the adult thymic medulla.HLA-G+ CD4 or CD8 cells have been identified in normal human peripheral blood and are thought to act as regulatory cells in that they are hypoproliferative with a unique cytokine profile differing from Tregs. The receptors for HLA-G are CD85j/ILT2, CD85d/ILT4, and CD158. Recent studies have shown a role for HLA-G in tolerance and maintece of transplanted organs. Applications Reported: This 87G antibody has been reported for use in flow cytometric analysis, and immunohistology staining of frozen tissue sections. Applications Tested: This 87G antibody has been tested by flow cytometric analysis of normal human peripheral blood. This can be used at less than or equal to 0.5 μg per test.
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.Specifications
HLA-G | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
P17693 | |
HLA-G | |
Primary | |
4° C | |
HLA-G |
87G | |
Flow Cytometry, Immunohistochemistry (Frozen) | |
Unconjugated | |
Mouse | |
Human | |
3135 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.