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Invitrogen™ HOXA11/HOXD11 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5101637
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Description
Antibody detects endogenous levels of total HOXA11/D11.
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
Specifications
| HOXA11/HOXD11 | |
| Polyclonal | |
| Unconjugated | |
| HOXD11 | |
| E230017H14Rik; homeo box 1I; homeo box 4F; homeo box A11; homeo box D11; homeobox A11; homeobox D11; homeobox protein Hox-1.9; Homeobox protein Hox-1I; homeobox protein Hox-4.6; Homeobox protein Hox-4F; homeobox protein Hox-5.5; homeobox protein HOXA11; Homeobox protein Hox-A11; homeobox protein Hox-D11; HOX1; Hox-1.9; HOX11; HOX1I; HOX4; Hox-4.6; Hox-4.6, mouse, homolog of; HOX4F; Hox-5.4; Hox-5.5; Hoxa11; Hoxa-11; HOXD11; Hoxd-11; LOC102553842; NEWGENE_1564605; RUSAT1; uncharacterized LOC102553842 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 15396, 15431, 3207, 3237 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P23813, P31270, P31277, P31311 | |
| HOXA11, HOXD11 | |
| A synthesized peptide derived from human HOXA11(Accession P31270), corresponding to amino acid residues P137-P187. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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