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Invitrogen™ HtrA1 Polyclonal Antibody
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Quantity:
100 μL
Unit Size:
100µL
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17218163 100 μL 100µL
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Product Code. 17218163 Supplier Invitrogen™ Supplier No. PA5115386

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total HTRA1.

HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HtrA1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene HTRA1
Gene Accession No. Q92743, Q9QZK5, Q9R118
Gene Alias AI429470; ARMD7; CADASIL2; CARASIL; High-temperature requirement A serine peptidase 1; HTRA; HtrA serine peptidase 1; Htra1; IGF binding; IGFBP5-protease; insulin-like growth factor binding protein 5 protease; L56; ORF480; protease serine 11; protease, serine, 11; protease, serine, 11 (IGF binding); PRSS11; RSPP11; serine protease; serine protease 11; Serine protease HTRA1; similar to bacterial htrA and degP
Gene Symbols HTRA1
Host Species Rabbit
Immunogen A synthesized peptide derived from human HTRA1(Accession Q92743), corresponding to amino acid residues Q371-T421.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56213, 5654, 65164
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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