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  5. Invitrogen™ Human 2B4/CD244 ELISA Kit

Invitrogen™ Human 2B4/CD244 ELISA Kit

Product Code. 17154703
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96 Tests
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17154703 96 Tests Pack of 96
17165179 5 x 96 Tests Each
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Product Code. 17154703 Supplier Invitrogen™ Supplier No. EH3RB

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Description

ELISA

Human 2B4/CD244 quantitates human 2B4/CD244 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human 2B4/CD244.

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number 2B4; C9.1; Cd244; CD244 long isoform; CD244 molecule; Cd244 molecule, natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR Nmrk; NKR2B4; Nmrk; non MHC restricted killing associated; Non-MHC restricted killing associated; signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4; transmembrane NK cell receptor 2B4
Assay Range 0.05 to 12 ng/mL
Assay Sensitivity 0.05 ng/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum, Supernatant
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 51744
Gene Symbol CD244
Interassay CV <12%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Label or Dye HRP
Quantity 96 Tests
Regulatory Status RUO
Sample Volume Plasma 50 μL, Serum 50 μL, Supernatant 50 μL
Storage Requirements 2°C to 8°C
Target CD244
Test Time 1 hrs 20 mins
Total Assay Time 4 hrs 45 mins
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