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Invitrogen™ Human alpha-2c Adrenergic Receptor (aa 333-359) Control Fragment Recombinant Protein

Product Code. 30201869
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30201869

Brand: Invitrogen™ RP100271

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (96%), Rat (96%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P18825
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 152
Name Human alpha-2 c Adrenergic Receptor (aa 333-359) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias [a]2 C; Adra 2 c; ADRA2C; Adra-2 c; ADRA2L2; ADRA2RL2; ADRARL2; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2 c; adrenergic, alpha-2 C-, receptor; Adrenergic, alpha2C-, receptor class I; adrenoceptor alpha 2 C; Alpha 2 CAR; alpha-2 adrenergic receptor subtype C4; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; alpha2C; Alpha-2 C adrenergic receptor; alpha-2 C adrenoceptor; Alpha-2 C adrenoreceptor; alpha2-C4; alpha-2 C-adrenergic receptor; ALPHA2CAR; alpha-2 CAR; Alpha-2 C-AR; subtype alpha2-C4
Common Name alpha-2 c Adrenergic Receptor
Gene Symbol ADRA2C
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence LTASRSPGPGGRLSRASSRSVEFFLSR
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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