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Invitrogen™ Human CDCA8 Synthetic Peptide

Product Code. 15398900
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Quantity:
50 μg
Unit Size:
50µg
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15398900 50 μg 50µg
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Product Code. 15398900 Supplier Invitrogen™ Supplier No. PEP0696

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Description

Synthetic Peptide

CDCA8 Synthetic Peptide, PEP-0696, from Invitrogen.

CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 55143
Species Human
Purification Method purified
Accession Number Q53HL2
Common Name Human CDCA8
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Symbol CDCA8
Lyophilized No
Preservative 0.02% sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO - research use only
Storage Buffer PBS
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