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ACROBiosystems Human FAP Protein, Fc Tag (active enzyme)

Product Code. 17156291
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Product Code. 17156291 Supplier ACROBiosystems Supplier No. FAPH526320ug

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Description

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 111.5 kDa. The protein migrates as 110-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Molecular Weight (g/mol) 111.5 kDa
Quantity 20 μg
Source Human FAP, Fc Tag (FAP-H5263) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 760 (Accession # Q12884-1).
Immunogen Leu 26 - Asp 760
Storage Requirements -20°C
Gene Alias FAP,FAPalpha,SIMP,Seprase,APCE
Common Name FAP
Conjugate Unconjugated
Species Human
Protein Tag Fc Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Enzymes
Purity or Quality Grade >90% as determined by SDS-PAGE
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