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Invitrogen™ Human Filaggrin 2 (aa 280-381) Control Fragment Recombinant Protein

Product Code. 30209748
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Quantity:
100 μL
Unit Size:
100µL
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30209748 100 μL 100µL
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Product Code. 30209748 Supplier Invitrogen™ Supplier No. RP94294

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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (68%), Rat (68%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55951 (PA5-55951. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The FLG2 protein is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. FLG2 is also required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q5D862
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 388698
Name Human Filaggrin 2 (aa 280-381) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias filaggrin family member 2; filaggrin-2; FLG2; FLG-2; Ifapsoriasin; IFPS; intermediate filament-associated and psoriasis susceptibility protein; intermediate filament-associated and psoriasis-susceptibility protein
Common Name Filaggrin 2
Gene Symbol FLG2
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence CGYSNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCG
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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