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Gibco™ Human IFN-alpha 2 (alpha 2b) (Carrier-Free) Recombinant Protein

Product Code. 10262493
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Quantity:
1 x 10^5 units
Unit Size:
Each
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Product Code. 10262493

Brand: Gibco™ PHC4064

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This item is not returnable. View return policy

Description

Recombinant Protein

Carrier-Free Dilution Recommendation: Further dilutions should be made in medium or buffered solution containing carrier protein such as PBS with 0.1% BSA. Storage: Store human IFN-Alpha 2 at -70°C. Upon initial thawing, apportion contents into working aliquots and store at -70°C. Avoid repeated freeze thaw cycles.

Interferon alpha-2b is a cytokine that belongs to the type I interferon family and is encoded by a gene cluster on chromosome 9. It is produced in response to viral infection and plays a key role in the innate immune response, exhibiting potent antiviral, antiproliferative and immunomodulatory properties. Interferon alpha-2b binds to a plasma membrane receptor consisting of IFNAR1 and IFNAR2, which is expressed ubiquitously in the body and can thus act on virtually all cells. This cytokine is effective in reducing the symptoms and duration of the common cold, and has shown efficacy in treating various types of cancer, including hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is considered a hallmark of severe COVID-19, and a combination therapy involving interferon alpha-2b may be a potential therapeutic approach. IFNA2 has been associated with diseases such as Severe Covid-19 and Hepatitis B.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01563
For Use With (Application) Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 3440
Molecular Weight (g/mol) 19.2 kDa
Name Human IFN-alpha 2 (alpha 2b) (Carrier-Free)
Purification Method Purified
Quantity 1 x 10^5 units
Storage Requirements -80°C
Regulatory Status RUO
Gene Alias alpha-2a interferon; IFNA; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFN-alpha-2; IFN-alphaA; INFA2; Interferon; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha-2; Interferon alpha-A; interferon, alpha 2; leIF A
Common Name Interferon alpha-2b
Gene Symbol IFNA2
Biological Activity Specific Activity = 2.38 x 10e8 units/mg; Assay used to measure bioactivity: interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981'Convenient Assay for Interferons,'J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981)'A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon,' in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394 ]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce 50% cytopathic effect. The units are determined with respect to the international reference standard for human interferon alphaA (Hu-IFN-α? provided by the National Institutes of Health [see Pestka, S. (1986)'Interferon Standards and General Abbreviations,' in Methods in Enzymology, Vol. 119 (S. Pestka, ed.), Academic Press, New York, 14-23 ]. The activity was determined with bovine MDBK cells challenged with vesicular stomatitis virus (VSV).
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Content And Storage -80°C
Activity Specific Activity = 2.38x10e8 units/mg; Assay used to measure bioactivity: interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981 Convenient Assay for Interferons, J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon, in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce 50% cytopathic effect. The units are determined with respect to the international reference standard for human interferon alphaA (Hu-IFN-α? provided by the National Institutes of Health [see Pestka, S. (1986) Interferon Standards and General Abbreviations, in Methods in Enzymology, Vol. 119 (S. Pestka, ed.), Academic Press, New York, 14-23]. The activity was determined with bovine MDBK cells challenged with vesicular stomatitis virus (VSV).
Shipping Condition Dry Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Liquid
Protein Subtype Interferons
Research Category Immunology, Virology, Oncology, Signal Transduction
Product Line Gibco
Purity or Quality Grade ≥95% by SDS-PAGE
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