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Gibco™ Human IFN-alpha A (alpha 2a) Recombinant Protein

Product Code. 10364733
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Quantity:
5 μg
Unit Size:
Each
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Product Code. 10364733

Brand: Gibco™ PHC4014

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Description

Recombinant Protein

Carrier-Free Dilution Recommendation: Further dilutions should be made in medium or buffered solution containing carrier protein such as PBS with 0.1% BSA.

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01563
For Use With (Application) Bioactivity
Formulation PBS with no preservative
Gene ID (Entrez) 3440
Molecular Weight (g/mol) 19.2 kDa
Name Human IFN-alpha A (alpha 2a)
Purification Method Purified
Quantity 5 μg
Storage Requirements -80°C
Regulatory Status RUO
Gene Alias alpha-2a interferon; Ifa2; IFNA; IFN-a; IFNA 2; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFN-alphaA; INFA2; Interferon; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family, gene 2; interferon alpha-2; Interferon alpha-A; interferon alpha-D; interferon, alpha 2; Interferon-alpha II; leIF A; leIF D; RP11-354P17.2
Common Name Interferon alpha-2
Gene Symbol IFNA2
Biological Activity Specific Activity = 2.5 x 10e8 units/mg; Assay used to measure bioactivity: Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981'Convenient Assay for Interferons,' J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981)'A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon,' in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394 ]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce 50% cytopathic effect. The units are determined with respect to the international reference standard for human interferon alpha (Hu-IFN-α provided by the National Institutes of Health [see Pestka, S. (1986)'Interferon Standards and General Abbreviations,' in Methods in Enzymology, Vol. 119 (S. Pestka, ed.), Academic Press, New York, 14-23 ]. The activity was determined using bovine MDBK cells challenged with vesicular stomatitis virus (VSV).
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Content And Storage -80°C
Classification Carrier-Free
Activity Specific Activity = 2.5x10e8 units/mg; Assay used to measure bioactivity: Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981 Convenient Assay for Interferons, J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon, in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce 50% cytopathic effect. The units are determined with respect to the international reference standard for human interferon alpha (Hu-IFN-α provided by the National Institutes of Health [see Pestka, S. (1986) Interferon Standards and General Abbreviations, in Methods in Enzymology, Vol. 119 (S. Pestka, ed.), Academic Press, New York, 14-23]. The activity was determined using bovine MDBK cells challenged with vesicular stomatitis virus (VSV).
Shipping Condition Dry Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Liquid
Protein Subtype Interferons
Research Category Immunology, Virology, Oncology, Signal Transduction
Product Line Gibco
Purity or Quality Grade ≥95%
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