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Gibco™ Human/Mouse/Rat BDNF, Animal-Free Recombinant Protein, PeproTech®

Product Code. 17896778
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250 μg
50 μg
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50µg
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17896778 50 μg 50µg
17806558 250 μg 250µg
17806528 2 μg 2µg
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Product Code. 17896778 Supplier Gibco™ Supplier No. AF4500250UG

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606.40 EUR valid until 2026-06-30
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Description

Recombinant Protein

Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P21237, P23363, P23560
For Use With (Application) ELISA, Functional Assay
Format Lyophilized
Formulation protein with no preservative
Gene ID (Entrez) 12064, 24225, 627
Molecular Weight (g/mol) 27 kDa
Name Human/Mouse/Rat BDNF, Animal-Free
Purification Method HPLC, SDS-PAGE
Quantity 50 μg
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Common Name BDNF
Gene Symbol BDNF
Biological Activity Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Content And Storage -20°C
Activity Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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