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ACROBiosystems Human Neuropilin-1 / NRP1 / CD304 Protein, Fc Tag

Product Code. 15837367
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1 mg
50 μg
Unit Size:
1mg
50µg
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15837367 50 μg 50µg
15827367 1 mg 1mg
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Product Code. 15837367 Supplier ACROBiosystems Supplier No. NR1H525250UG

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Description

Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.5 kDa. The protein migrates as 105-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number AAH07533
Molecular Weight (g/mol) 96.5 kDa
Quantity 50 μg
Source Human NRP1, Fc Tag (NR1-H5252) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Lys 644 (Accession # AAH07533).
Immunogen Phe 22 - Lys 644
Storage Requirements -20°C
Gene Alias NRP1,Neuropilin-1,NRP,VEGF165R,CD304
Common Name Neuropilin-1
Conjugate Unconjugated
Species Human
Protein Tag Fc Tag
Buffer Tris with Glycine, Arginine and NaCl, pH7.5
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Bio-Markers and CD Antigens
Purity or Quality Grade >90% as determined by SDS-PAGE
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