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STEMCELL Technologies Human Recombinant DKK-1

Product Code. p-7217458
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Quantity:
1000 μg
50 μg
Unit Size:
1000µg
50µg
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Product Code. 17119841

Brand: STEMCELL Technologies 78208.1

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This item is not returnable. View return policy

Description

Dickkopf-related protein 1

  • Dickkopf-related protein 1 (DKK-1) is a member of the Dickkopf family and is a secreted protein that inhibits the canonical WNT pathway by competitive binding to low-density lipoprotein receptors (LRP)-5 and 6 with high affinity, thereby decreasing β-catenin protein stability (Niehrs)
  • DKK-1 regulates embryonic development and contains two conserved cysteine-rich domains separated by a linker region and an N-terminal signal peptide
  • A family of human DKK-related genes composed of DKK-1, DKK-2, DKK-3, and DKK-4 have been characterized together with a unique DKK-3 related protein termed Soggy
  • DKK-1 has been shown to support the generation of myeloid-derived suppressor cells (MDSCs) and thus is a negative regulator of antitumor immune responses
  • DKK-1 from thrombocytes is an important regulator of leukocyte infiltration and induces Th2 cell polarization and potentiates

Specifications

Name Dickkopf-1, Dickkopf WNT signaling pathway inhibitor 1, hDkk-1, SK
Quantity 50 μg
Cell Type Endoderm, PSC-Derived; Myeloid Cells; Pluripotent Stem Cells
Purity or Quality Grade ≥95%
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