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STEMCELL Technologies Human Recombinant PDGF-AB

Product Code. 17109561
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Product Code. 17109561

Brand: STEMCELL Technologies 78096

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This item is not returnable. View return policy

Description

Platelet-derived growth factor AB

  • Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark & Heldin)
  • PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta
  • It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.) PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells
  • PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.) It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan et al.)

Specifications

Name GDGF, Glioma-derived growth factor, ODGF, Osteosarcoma-derived growth factor, Platelet-derived growth factor-AB
Quantity 10 μg
Cell Type Mesenchymal Cells, PSC-Derived; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons; Osteoblasts; Other
Purity or Quality Grade ≥95%
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