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STEMCELL Technologies Human Recombinant RANKL, ACF
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100 μg
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100µg
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500µg
Description
- Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.) Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan)
- RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.) RANKL binds to the receptor activator of nuclear factor kappa-B (RANK)
- Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.) Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.) RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.) This product is animal component-free
Specifications
Specifications
| Name | CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoclast differentiation factor, soluble Receptor activator of NF-κB ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TNF superfamily member 11, TNLG6B, Tumor necrosis factor superfamily member 11, TRAN |
| Quantity | 100 μg |
| Cell Type | Airway Cells; Cancer Cells and Cell Lines; Dendritic Cells; Intestinal Cells; Mammary Cells; Osteoblasts; Other; Pancreatic Cells; Prostate Cells; T Cells |
| Purity or Quality Grade | ≥95% |
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