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Invitrogen™ Human RIM1 (aa 1158-1232) Control Fragment Recombinant Protein

Product Code. 30199863
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Quantity:
100 μL
Unit Size:
100µL
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30199863 100 μL 100µL
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Product Code. 30199863 Supplier Invitrogen™ Supplier No. RP109568

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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (91%), Rat (91%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-140003 (PA5-140003. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q86UR5
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 22999
Name Human RIM1 (aa 1158-1232) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias C030033M19Rik; CORD7; Kiaa0340; mKIAA0340; Nbla00761; Rab3 effector; Rab3 interacting protein 1; Rab-3-interacting molecule 1; rab3-interacting molecule 1; rab-3-interacting protein 1; rab3-interacting protein 1; Rab-3-interacting protein 2; RAB3-interacting protein 2; Rab3ip1; RAB3IP2; regulating synaptic membrane exocytosis 1; regulating synaptic membrane exocytosis 1 beta; regulating synaptic membrane exocytosis protein 1; Rim; RIM 1; RIM1; RIM1a; RIM1alpha; Rim1b protein; Rims1; Serg1; synaptic exocytosis regulator 1
Common Name RIM1
Gene Symbol Rims1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence ENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHL
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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