missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. Gibco™ Human IL-12 Receptor beta-1 (soluble) Fc Recombinant Protein, PeproTech®

Gibco™ Human IL-12 Receptor beta-1 (soluble) Fc Recombinant Protein, PeproTech®

Product Code. 17819285
Change view
Click to view available options
Quantity:
1 mg
100 μg
20 μg
250 μg
500 μg
Unit Size:
100µg
1mg
20µg
250µg
500µg
5 product options available for selection
Product selection table with 5 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
17819285 20 μg 20µg
17819675 500 μg 500µg
17839315 100 μg 100µg
17849245 1 mg 1mg
17859485 250 μg 250µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 5 options available.
5 options
This item is not returnable. View return policy
Product Code. 17819285 Supplier Gibco™ Supplier No. 20012RB120UG

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Protein

Recombinant Human sIL-12 Receptor Beta-1 Fc has a calculated molecular weight of 84.3 kDa and contains 758 amino acid residues, which consists of the extracellular domain of IL-12R Beta-1 fused to the Fc portion of human IgG and contains a C-terminal His-tag. Due to glycosylation, it migrates at an approximate molecular weight of 116 kDa, under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P42701
For Use With (Application) Functional Assay
Format Lyophilized
Formulation protein with no preservative
Gene ID (Entrez) 3594
Molecular Weight (g/mol) 84.3 kDa
Name Human IL-12 Receptor beta-1 (soluble) Fc
Purification Method HPLC, SDS-PAGE
Quantity 20 μg
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias CD212; cluster of differentiation 212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL12R; IL-12 R subunit beta-1; IL-12 R[b]; IL12RB; Il12rb1; IL-12 RB1; IL-12 R-BETA1; IL-12 R-beta-1; IMD30; interleukin 12 receptor subunit beta 1; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; Interleukin-12 receptor beta-1 chain precursor (IL-12 R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component); interleukin-12 receptor subunit beta-1; MGC34454
Common Name IL12RB1
Gene Symbol IL12RB1
Biological Activity Human IL-12 Receptor β-1 Fc activity is measured by its ability to bind to Human IL-12p70 in a functional ELISA.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag, His-tag
Sequence CRTSECCFQD PPYPDADSGS ASGPRDLRCY RISSDRYECS WQYEGPTAGV SHFLRCCLSS GRCCYFAAGS ATRLQFSDQA GVSVLYTVTL WVESWARNQT EKSPEVTLQL YNSVKYEPPL GDIKVSKLAG QLRMEWETPD NQVGAEVQFR HRTPSSPWKL GDCGPQDDDT ESCLCPLEMN VAQEFQLRRR QLGSQGSSWS KWSSPVCVPP ENPPQPQVRF SVEQLGQDGR RRLTLKEQPT QLELPEGCQG LAPGTEVTYR LQLHMLSCPC KAKATRTLHL GKMPYLSGAA YNVAVISSNQ FGPGLNQTWH IPADTHTEPV ALNISVGTNG TTMYWPARAQ SMTYCIEWQP VGQDGGLATC SLTAPQDPDP AGMATYSWSR ESGAMGQEKC YYITIFASAH PEKLTLWSTV LSTYHFGGNA SAAGTPHHVS VKNHSLDSVS VDWAPSLLST CPGVLKEYVV RCRDEDSKQV SEHPVQPTET QVTLSGLRAG VAYTVQVRAD TAWLRGVWSQ PQRFSIEGGP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHHHH
Content And Storage -20°C
Activity Human IL-12 Receptor β-1 Fc activity is measured by its ability to bind to Human IL-12p70 in a functional ELISA.
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥98% by SDS-PAGE gel and HPLC analyses.
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.