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Ambion™ mirVana™ miRNA Inhibitor, let-7c positive control

mirVana™ miRNA Inhibitor, let-7c positive control

€ 402.00 - € 1218.00

Specifications

Label or Dye Unconjugated
Purification Method Purified
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
13315384
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Ambion™
4464080
5 nmol
€ 402.00
5nmol
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13325384
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Ambion™
4464081
20 nmol
€ 1218.00
20nmol
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Estimated Shipment: 10-04-2024
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Description

Description

miRNA inhibitors are small, chemically modified single-stranded RNA molecules designed to specifically bind to and inhibit endogenous miRNA molecules and enable miRNA functional analysis by down-regulation of miRNA activity.

We have now released the second generation of miRNA inhibitors, mirVana™ miRNA Inhibitors which:
  • Display better potency than lead competitor's product
  • Offer maximum and consistent effect in vitro at low miRNA inhibitor concentration
  • Are non toxic
  • Target the most updated Sanger content
  • Can be used in vitro and in vivo, offering consistency throughout your entire research project

    Positive and negative controls are also available for use along with mirVana™ miRNA Inhibitors in miRNA down-regulation experiments.

    mirVana™ miRNA Inhibitor let-7c Positive Control
    The mirVana™ miRNA Inhibitor let-7c Positive Control is intended for use as a positive control for mammalian cell culture experiments using mirVana™ miRNA Inhibitors. Endogenous let-7c miRNA has been shown to negatively regulate HMGA2 mRNA in cultured cells. HMGA2 is a ubiquitously expressed, nonhistone, chromatin protein that can modulate gene expression through changes in chromatin architecture. let-7c miRNA down-regulates levels of HMGA2 mRNA. When transfected into human and mouse cell lines, let-7c miRNA inhibitor blocks endogenous let-7c miRNA, resulting in increased levels of HMGA2 mRNA. Thus, let-7c miRNA inhibitor activity can be monitored in human or mouse cells using real-time reverse transcription PCR (RT-PCR) to detect HMGA2 mRNA.

    First Generation Inhibitor Controls
    Our first-generation miRNA inhibitors (and controls), Ambion™ Anti-miR™ miRNA Inhibitors, have lower specificity and potency, plus a lower strand specificity compared to the new mirVana™ miRNA Inhibitors. These first-generation inhibitors are recommended for completing ongoing in vitro miRNA studies. For new studies or in vivo studies, we highly recommend our new mirVana™ miRNA Inhibitors and their corresponding controls.
Specifications

Specifications

Unconjugated
Purified
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Product Certifications

For Research Use Only. Not for use in diagnostic procedures.