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Invitrogen™ IFN beta Monoclonal Antibody (MMHB-3)

Product Code. 11804221
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Quantity:
50 μg
Unit Size:
50µg
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11804221 50 μg 50µg
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Product Code. 11804221 Supplier Invitrogen™ Supplier No. 214001

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Description

Mouse Monoclonal Antibody

Specificity: Neutralizes human interferon beta. For best results in experiments involving neutralization of the anti-viral effect of human interferon beta we recommend using sheep polyclonal antibody to human interferon beta (Product # 314001). Activity: Interferon was titrated with the use of the cytopathic effect inhibition assay, where 1 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of human IFN beta to an endpoint of 50%. Purity is >95%. Endotoxin level <1 EU/ug. Store at -20°C for short-term use (less than 6 months). For long-term storage, aliquot and store at -70°C or below for retention of full activity, avoiding freeze/thaw cycles. Packaged by and distributed for PBL Assay Science.

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFN beta
Applications ELISA, Neutralization
Classification Monoclonal
Clone MMHB-3
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene Ifnb1
Gene Accession No. P01574
Gene Alias Fibroblast interferon; Ifb; IFF; IFN b; IFN β; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNβ; Interferon; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
Gene Symbols Ifnb1
Host Species Mouse
Immunogen human interferon beta.
Purification Method Size-exclusion chromatography, Ion-exchange chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3456
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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