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Invitrogen™ IL-10 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148443
This item is not returnable.
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Description
Reconstitute at 1 mg/mL in sterile PBS.
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Specifications
| IL-10 | |
| Polyclonal | |
| Unconjugated | |
| IL10 | |
| CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF | |
| Goat | |
| Protein A/G | |
| RUO | |
| 3586 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Neutralization, Western Blot | |
| 1 mg/mL | |
| PBS with trehalose and no preservative | |
| P22301 | |
| IL10 | |
| S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-10, Ser19-Asn178. | |
| 1 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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