IL-22, APC, clone: IL22JOP, eBioscience™
Rat Monoclonal Antibody
Merk: Affymetrix eBioscience 17-7222-82
Overige gegevens : Gewicht : 0.25000kg
BeschrijvingDescription: The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis.IL22JOP is published to recognize rhesus IL-22.Applications Reported: This IL22JOP antibody has been reported for use in intracellular staining followed by flow cytometric analysis.Applications Tested: This IL22JOP antibody has been tested on Th17-polarized CD4+ normal human peripheral blood cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|Interleukin-22, IL22, IL-10-related T-cell-derived-inducible factor, IL-TIF|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
For Research Use Only.