Invitrogen™ IL21R Polyclonal Antibody

Description

Immunogen sequence: GVSMPRGWAA PLLLLLLQGG WGCPDLVCYT DYLQTVICIL EMWNLHPSTL TLTWQDQYEE LKDEATSCSL HRSAHNATHA TYTCHMDVFH FMADDIFSVN ITDQSGNYSQ ECGSFLLAES IKPAPPFNVT VTFSGQYNIS WRSDYEDPAF YMLKGKLQYE LQYRNRGDPW AVSPRRKLIS VDSRSVSLLP LEFRKDSSYE LQVRAGPMPG SSYQGTWSEW S; Positive Samples: U-87MG, Mouse spleen, Mouse thymus; Cellular Location: Membrane, Single-pass type I membrane protein.

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.