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  7. Thermo Scientific Chemicals Indomethacin

Thermo Scientific Chemicals Indomethacin

Product Code. 15462202 Shop All Thermo Scientific Chemicals Products
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Product Code. 15462202

Brand: Thermo Scientific Chemicals 458030050

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Descrizione

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release

• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics

• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions

• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 53-86-1
Molecular Formula C19H16ClNO4
Molecular Weight (g/mol) 357.79
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Synonym indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifica

Melting Point 155.0°C
Loss on Drying 0.5% max. (100°C, 2 h, 5 mm Hg)
Infrared Spectrum Authentic
Quantity 5 g
Formula Weight 357.79
Percent Purity ≥97.5% (HPLC)
Chemical Name or Material Indomethacin

Sicurezza e movimentazione

compliance-icons compliance-icons
Identificativo prodotto
  • Indomethacin
 Avvertenza
  • Danger
 Categoria di pericolo
  • Acute toxicity Category 1
  • Skin sensitiser Category 1
  • Reproductive toxicity Category 1B
 Indicazioni di pericolo
  • H300-Fatal if swallowed.
  • H317-May cause an allergic skin reaction.
  • H360FD-May damage fertility. May damage the unborn child.
 Consigli di prudenza
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P330-Rinse mouth.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
SDS

RUO – Research Use Only

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