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STEMCELL Technologies Indomethacin

Product Code. 17190292
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1 g
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Product Code. 17190292 Supplier STEMCELL Technologies Supplier No. 73942

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Description

Inhibits COX-1 and COX-2

  • Indomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.) Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 μM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.)
  • Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.)
  • Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.)
  • Inhibits growth of mouse mammary tumors (Fulton)
  • Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.)

Specifications

CAS 53-86-1
Synonym Indocin
Quantity 1 g
Molecular Formula C19H16ClNO4
Purity ≥99%
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