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Invitrogen™ INSR alpha Chimeric Recombinant Rabbit Monoclonal Antibody (83-14)
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Product Code. 17980841
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Quantity:
200 μg
Unit Size:
200µg
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17980841 200 μg 200µg
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Product Code. 17980841 Supplier Invitrogen™ Supplier No. MA547791

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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Recognises the extracellular domain of the Insulin Receptor alpha. Amino acids 469-592 (exon 7 and 8) of Insulin Receptor alpha.

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
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Specifications

Antigen INSR alpha Chimeric
Applications ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone 83-14
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene INSR
Gene Accession No. P06213
Gene Alias 4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B
Gene Symbols INSR
Host Species Rabbit
Immunogen This antibody was raised by immunizing mice with IM-9 lymphocytes followed by purified insulin receptor.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3643, 396755, 408017, 443431
Target Species Human, Bovine, Sheep, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
Target Molecule Tag
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