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Invitrogen™ INSR Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA529286
This item is not returnable.
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Description
Predicted reactivity: Mouse (97%), Rat (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
Specifications
| INSR | |
| Polyclonal | |
| Unconjugated | |
| INSR | |
| 4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 3643 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.67 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| P06213 | |
| INSR | |
| Recombinant protein encompassing a sequence within the center region of human Insulin Receptor. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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